Research in the Lorieau group integrates Biophysics, Physical Chemistry, Structural Biology and Biochemistry in elucidating the interplay between biomolecular structure, dynamics, chemistry and function. With a combination of solution- and solid-state Nuclear Magnetic Resonance spectroscopies, computational tools and other biophysical methods, our research focuses on membrane protein structure and dynamics, membrane protein biochemistry, the development of theory and techniques to enhance the precision and resolution of structural and dynamic information by NMR, and the investigation of molecular dynamics as it relates to enzymatic catalysis and kinetics.
- Membrane protein and membrane channel structure, dynamics and function
- Methods for the high-resolution characterization of structure and dynamics for solution-state and solid-state nuclear magnetic resonace of large molecular-weight biomolecules
- Software development for the simulation of magnetic resonance, including data and statistical analysis of multidimensional datasets